Formulation And Evaluation Of Ibuprofen Tablets Using Sago (Metroxylon sagu Rottb.) Starch as A Binder
Nurul Auliasari (a*), Akmal Akmal (b), Aji Najihudin (a), Annisa Fadhilah (a), Siti Hindun (a)

a) Program Studi Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam (FMIPA), Universitas Garut, Jl. Raya Samarang No. 52A, Garut 44151, Indonesia
*nurul[at]uniga.ac.id
b) Lembaga Farmasi Direktorat Kesehatan Angkatan Darat, Jl. Gudang Utara No. 26, Merdeka, Sumur Bandung, Kota Bandung 40113, Jawa Barat, Indonesia

Abstract

Sago is a staple food for most of the world population, its use is not only used in food products but also used in pharmaceutical products. Sago starch can be used as a binding material on tablets. This study aimed to develop formulation and evaluation of ibuprofen tablets using sago (Metroxylon sagu Rottb.) starch as a binder in making ibuprofen tablet preparations. Tablets made using wet granulation method with sago starch as a binder at various concentration. The evaluation includes of the granules and tablets. The result from dissolution test of ibuprofen tablets showed that the highest dissolved percentage was obtained in formula 1 compared to formulas 2 and 3. The results showed that sago starch could be used as binders on tablets and fulfilled the requirements on the evaluation of the granules and tablets.

Keywords: Ibuprofen; Metroxylon sagu Rottb; Binder; Tablets

Topic: Pharmacology