(a). Faculty of Medicine, Nursing, and Public Health, Universitas Gadjah Mada, Yogyakarta, Indonesia
*nayakasih[at]gmail.com
(b). Faculty of Medicine and Health Science, Universitas Warmadewa, Denpasar, Indonesia
(c). Faculty of Medicine, Universitas Tadaulako, Palu, Indonesia
Abstract
Inflammation is a local reaction from living tissue or cells to a stimulation or injury. This anti-inflammatory test aims to determine the effect of anti-inflammatory treatment on changes in edema volume in rat’s feet after induced by carrageenan. Anti-inflammatory that is used in this research is celecoxib. Celecoxib is a non-steroidal anti-inflammatory agent that works by inhibiting selective cyclooxigenase enzymes. In this pharmacological screening test, 2 wistar strains of white rats were tested, which were weighed before anti-inflammatory administration. The rats were divided into 2 groups, namely the negative and positive control group. As for the negative control, the treatment was given 0.9% NaCl as much as 4 mL per oral, while for positive control was given celecoxib 100 mg / 55.5 ml. the volume of edema in the rat’s feet was measured using pletismometer. We found that there was no significant difference in the volume of edema between the group given 0.9% NaCl and the group given celecoxib. Therefore, we conclude that celecoxib as an anti-inflammatory agent is not able to inhibit edema in rat’s feet.
