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901	Mathematics	ABS-612
A Mathematical Model of the Cognitive Semantics of the English Preposition on Ruswan Dallyono, Didi Sukyadi Universitas Pendidikan Indonesia Abstract A mathematical approach to linguistics provides an array of insights for quantitative description on the ways language works. This area of investigation is still underexplored, but it is actually significant for the development of mathematical models to enhance linguists’ understanding on linguistic structure. This study aims to present a mathematical analysis of how the English preposition on works under the framework of Trajector (TR) and Landmark (LM) relations (Tyler & Evans, 2003). Data were corpora taken from 10 dissertations written by American student writers. To sort the data, Ant Conc 3.4.1.0 was used to parse clauses or sentences based on the TR-LM configurations. Based on the TR-LM configurations, a mathematical model was developed to discover how these variables are quantitatively related to the number of senses produced by using a geometric representation of TR and LM. This study indicates that the relation between TRs and LMs, on the one hand, and the potential sum of senses, on the other, follows the integral function of ∑ C = ∫ TR d(LM), which means that the total number of senses of C equals the integral of TR with respect to LM. This mathematical modeling confirms the TR-LM hypothesis that every physical object has a unique sense established by their TR-LM configuration as spawned by Lakoff (1987). Keywords: Keywords: construal, sense, preposition, trajector, landmark PermaLink | Plain Format | Corresponding Author (Ruswan Dallyono)

902	Mathematics	ABS-872
Analysis Of Geometry Learning Materials In Developing E-Module With Inquiry Approach Dyah Triwahyuningtyas, I Ketut Suastika Universitas Kanjuruhan Malang, Indonesia Abstract The development of online teaching materials technology makes it easier for students to study anywhere and anytime. In general, students still experience difficulties in understanding the material of the material in learning geometry. Therefore, the purpose of this study is to analyze geometry learning material in developing e-modules with an inquiry approach. This study applies the research and development method of Plomp in the preliminary research phase. The data analysis technique used is descriptive quantitative and qualitative data analysis. The results of this study are geometry learning material in elementary school teacher education students including material two-dimentional figure and space geometry. Geometry learning material that was previously used by students still gives the concept in finished form, so students only memorize in understanding the concept. Implementation of the results of the material analysis will be developed teaching materials in the form of e-modules for learning geometry with the inquiry approach. Keywords: E-module, Inquiry, Two-Dimentional Figure PermaLink | Plain Format | Corresponding Author (Dyah Triwahyuningtyas)

903	Mathematics	ABS-874
Teaching "Calculating blanket area, volume of tube, and cone" For deaf junior high school students Dini Handayani, Achmad Hufad, Sunardi Tukimin, Endang Rochyadi, Asep Bayu Dani Nandiyanto Universitas Pendidikan Indonesia Jl. DR. Setiabudhi No.229, Isola, Sukasari, Kota Bandung, Jawa Barat 40154 Sekolah Pascasarja Prodi Pendidikan Khusus Abstract This study aims to find out how to teach calculating the area of ​​blankets, tube volumes, and cones for middle-aged deaf students. This study uses the single subject method. The research subjects were 4 second grade students of junior high school in a special school in Bandung Regency. The research data was taken by pre-test and post-test. Teaching uses total communication and explanation. The results of the study show that calculating the area of ​​blankets, volume of tubes, and cones for deaf students should be given examples and giving as many questions as possible. Giving examples and questions must be various types so students can understand Keywords: deaf, cone, tube PermaLink | Plain Format | Corresponding Author (Dini Handayani)

904	Mathematics	ABS-1134
The Category of Supermodules Ibnu Hadi*, Makmuri, Sudarwanto Department of Mathematics, Faculty of Mathematics and Science, Universitas Negeri Jakarta, Jl. Rawamangun Muka, Jakarta, 13220, Indonesia Abstract Let be commutative algebra with unit element and be an -module. Let be class of all pairs of -modules where is direct sum of and contains . In this article we give a method for defining morphism between two objects in so that become category. Keywords: Category; Supermodules PermaLink | Plain Format | Corresponding Author (ibnu hadi)

905	Mathematics	ABS-889
Development of Property Rental Insurance Model Sudarwanto, Lukita Ambarwati, Ibnu Hadi Universitas Negeri Jakarta Abstract In this paper we developed insurance model on property rental business. We used Generalized Linear Models(GLM) to develop this model because the data on property rental matches to the characteristics of GLM. Analysis of the model is done by looking at the relationship between the distribution functions that are most widely used in the analysis of property rental data. The models for the relations of distribution functions are: Poisson-Gamma, Poisson-Inverse Gauss, Negative Binomial-Gamma and Negative Binomial-Inverse Gauss. The relationship between distributions is seen from the root-mean-squared error (RMSE) and absolute mean error (MAE). Simulation results show that the model formed in the case of random effects increases in standard deviation values also increases the variation value on the average estimator. This is in accordance with the condition that the addition of standard deviation means that there is an increase in the variance of the data. Keywords: Property Rental Insurance, Generalized Linear Models PermaLink | Plain Format | Corresponding Author (Lukita Ambarwati)

906	Mathematics	ABS-890
ANALYSIS OF MATHEMATICAL LEARNING MATERIALS WITH THE CHARACTERISTICS OF REALISTIC MATHEMATICS IN THE DESIGN RESEARCH STUDENT THESES IN THE MATHEMATICAL EDUCATION STUDY PROGRAM FMIPA UNJ Pinta Deniyanti Sampoerno Universitas Negeri Jakarta Abstract This study focuses on analyzing the theses of Mathematics Education Study Program students who are Design Research (DR) types. Thesis is analyzed with the aim to see the relationship between mathematics learning material with the characteristics of Realistic Mathematics Education. DR is a quite complex qualitative research and requires precision and creativity in preparing realistic mathematics learning. The emphasis of DR is on the process of delivering subject by teachers to students and the resulting product in the form of learning design which is part of the Hypothesis Learning Trajectory. Relational analysis in this study is in the form of error analysis as an effort to observe and describe deviations between mathematical concepts to be taught to students with mathematical contextual material to be appointed in research for every mathematical material that is described as human activity. Relational understanding produces conceptual knowledge, allows students to solve mathematical problems conceptually and can explain the strategies and steps used. From 36 DR theses, there are some learning materials which is felt to be very contextually forced, so that relational understanding is not achieved. But if it is right, not only acheived relational understanding, but also students mathematics learning outcomes increased. Keywords: Design Research Error Analysis, Relational Understanding, Characteristics of Realtistic Mathematics Education PermaLink | Plain Format | Corresponding Author (Ratna Widyati)

907	Mathematics	ABS-637
Methods to compute determinant of a 3x3 matrix Esih Sukaesih (a*), Cucu Cahyati (a), Elis Ratna Wulan (a) UIN Sunan Gunung Djati Bandung Abstract Sarrus’s method is a rule to compute the determinant of a 3x3 matrix, by write out six entries of matrix (two columns or rows of matrix). Recently in 2014, Hajrizaj gave three new methods to compute determinant of a 3x3 matrix, by write out four entries of a 3x3 matrix. We expand the Hazrijaz’s method into fourteen method to compute determinant of a 3x3 matrix. Keywords: matrix, determinant, Sarruss method PermaLink | Plain Format | Corresponding Author (Esih Sukaesih)

908	Mathematics	ABS-397
Didactical Design to Overcome Learning Obstacles about Relationship between Central Angle, Length of Arc, and Area of Segment of the Circle Mimi Nur Hajizah (*), Dwi Antari Wijayanti, Puspita Sari Universitas Negeri Jakarta Abstract This research aims to develop a didactical design of learning about circle at junior high school, especially the relationship between central angle, length of arc, and area of segment of the circle. Developed didactical design consists of three activities obtained from three formal stages during the research process. The first stage is the analysis of the didactical situation before learning to obtain a hypothetical didactical design. Preparation of hypothetical didactical design is preceded by a preliminary study which includes the identification of obstacles student learning as well as the theoretical analysis and repersonalisasi. Identification of learning obstacle is conducted at a junior high school in South Jakarta involving 34 students of class IX by analyzing the results of the students answers on the questions provided, analyzing the results of interviews of teachers and students, as well as analyzing the textbooks used at the schools. The second stage is the analysis metapedadidaktic which is reflected in the design implementation. Design implementation is conducted at junior high school where a preliminary study done involving 36 students of class VIII. The third stage is the stage of reflection by conducting a retrospective analysis. This is done in order to obtain information for a revised design to produce empirical didactical design. The developed empirical didactical design allows for further development through the three stages of the same formal. Keywords: didactical design; mathematics; learning obstacle; circle PermaLink | Plain Format | Corresponding Author (Mimi Nur Hajizah)

909	Mathematics	ABS-668
Analysis Of Normality Of Quotient Subgroup On Matrices Integers Modulo Prime Ibnu Hadi (a*), Selly Anastassia Amellia Kharis (a) a) Faculty of Mathematics and Natural Science, Universitas Negeri Jakarta, Jalan Rawamangun Muka, Jakarta 13220, Indonesia *ibnu_unj[at]yahoo.co.id Abstract A set of matrices integers modulo prime can form a finite group. This group has trivial and non-trivial subgroups. The trivial subgroup is normal clearly and for a non-trivial subgroup the normal properties will be investigated. Furthermore, if a non-trivial subgroup is a normal subgroup, then a quotient subgroup can be constructed. This paper discusses the characteristics of normality of quotient subgroup on matrices integers modulo prime. A group is constructed by matrices integers modulo prime. Here we considered some properties of this group. The order of group play an important role in this quotient subgroup. By this concept, we derive some result of normality of quotient subgroup. From this paper, it was found that the subgroup order had an effect on the normality of a quotient subgroup. Keywords: Order of Group, Normality of Quotient Subgroup, Matrices Integers Modulo Prime PermaLink | Plain Format | Corresponding Author (ibnu hadi)

910	Mathematics	ABS-936
Determination of Width Control of Dispersion Process for Single Sample Size in Multivariate Case with Many P=4 Variables Enjang AS (1), Farid Soleh Nurdin (1), Wawan Setiawan(2), Iwan Gunawan (3), Eri Subekti (2) 1) Universitas Islam Negeri Sunan Gunung Djati, Jl. A.H. Nasution No.105, Cipadung, Cibiru, Kota Bandung 2) Universitas Pendidikan Indonesia, Jl. Dr. Setiabudi no 229, Bandung 3) Universitas Langlangbuana, Jl. Karapitan no.116, Bandung Abstract In this study, we discussed the control of multivariate dispersion statistics for a single sample size. The control chart was developed from a multivariate control chart exponentially weighted mean square (MEWMS) with total variance (TV) as the multivariate dispersion size used. Although the MEWMS control chart has more advantages than MEWMA and MCUSUM control charts, it has limitations because it only applies to p = 3 variables. Therefore, the main focus in this study is to determine the L value as a determinant of the MEWMS control boundary width for the variable p = 4 through the simulation method. Based on historical data on controlling the wing component products of Airbus aircraft through simulations with vector mean parameters and covariance matrices, MEWMS Control Chart is quick in detecting changes in variance, while in detecting the average changes is very slow. Keywords: Dispersion, Total Variance, Covariance Matrix PermaLink | Plain Format | Corresponding Author (Farid Soleh Nurdin)

911	Mathematics	ABS-432
Spatial Thinking Ability and Student Mathematical Characteristics through 3D Cabri with the Scientific Approach R Kariadinata 1, J Juariah 1, R Poppy Yaniawati 2, H Sugilar 1, A Muthmainah 1 1 Department Mathematics of Education, UIN Sunan Gunung Djati Bandung 2 Department Mathematics of Education, Universitas Pasundan *rahayu.kariadinata[at]uinsgd.ac.id Abstract The purpose of this study was to determine the differences in the increase in students spatial thinking abilities; differences in achievement of spatial thinking skills based on students Early Mathematics (PAM) knowledge; and the difference in increasing the mathematical character of students between before and after mathematics learning using the Cabri 3D software with a scientific approach. This study uses quasi-experiment, the experimental class uses Cabri 3D software with a scientific approach and the control class uses conventional learning. The results showed that: there were differences in the increase in spatial thinking skills; there are differences in achievement of spatial thinking skills based on PAM and there is interaction between PAM categories of students with learning in achieving students spatial thinking skills; there is a difference in the improvement of students mathematical characters between before and after mathematics learning using the Cabri 3D software with a scientific approach. Mathematics learning using Cabri 3D software with a scientific approach is one alternative to improve spatial thinking skills and mathematical character of students Keywords: scientific approach, spatial thinking, mathematical characters PermaLink | Plain Format | Corresponding Author (Hamdan Sugilar)

912	Mathematics	ABS-948
Analysis of Indicators achievement Habits of Mind (HoM) Senior High School Student. Masta Hutajulu(a,b*), and Wahyudin Wahyudin(a) a)Postgraduat Departement of Mathematics Education, Universitas Pendidikan Indonesia, Jl. Dr. Setiabudhi 229, Bandung 40154, Indonesia b)Departement of Mathematics Education, IKIP Siliwangi, Jl. Terusan Jenderal Sudirman, Cimahi 40526, Indonesia * masthahutajulu[at]student.upi.edu Abstract Abstract. This study aims to analyze the achievement of each indicators habits of mind (HoM) senior high school students. The research method used is descriptive. The population in this study were high school students in the city of Bandung. The sample was chosen by 1 class consisting of 31 students. The instrument used was the Habits of Mind questionnaire. The results showed that the habits of mind of senior high school students were positive for the 16 indicators and were at moderate to high levels. This study can be recommended to improve the habits of mind (HoM) senior high school students. Keywords: Habits of mind, indicators PermaLink | Plain Format | Corresponding Author (Masta Hutajulu)

913	Mathematics	ABS-693
How Effective is the Vaccine in Reducing Outbreak of Diphtheria? Fadilah Ilahi, Nenden Siti Nurkholipah UIN Sunan Gunung Djati Bandung Abstract Indonesia suffered a diphtheria outbreak in the late of 2017 after the last case in the 1980s. Over the years, DPT (Diphtheria Pertussis Tetanus) vaccine is believed to be the only ways of preventing diphtheria outbreaks. The Indonesian government requires all infants aged 2-4 months old to get DPT vaccine in order to get the immunity against diphtheria-causing bacteria with a single dose of vaccine on each month. The problem is when some infants do not have the complete vaccine so the effectiveness of DPT vaccine is need to be questioned. In this paper, the authors try to construct the model to see how effective the DPT vaccine for those cases. The population assumed to be closed population and consisted of SIR (Susceptible, Infected, and Recovery) population and the vaccine notated as a function of a dose that has taken by the infant. Furthermore, this model will be analyzed the stability using eigen values and basic reproduction number (R_0). The simulation is done to provide an overview of the effectiveness of the vaccine dynamically. Analysis and simulation results show that complete dose of DPT vaccine plays an effective role in reducing the spread of diphtheria. Keywords: Diphtheria, vaccine, outbreak, epidemic, basic reproduction number, mathematical model PermaLink | Plain Format | Corresponding Author (Fadilah Ilahi)

914	Mathematics	ABS-443
Structure Sense Mathematics with Construct 2 and Sticky Notes H Sugilar 1*, R Kariadinata 1, N Sobarningsih 1, RD Agustina2 1 Department Mathematics of Education, UIN Sunan Gunung Djati Bandung 2 Department Physics of Education, UIN Sunan Gunung Djati Bandung * hamdansugilar[at]uinsgd.ac.id Abstract The purpose of this study was to determine the ability of the mathematical structure sense and attitudes of students through learning with construct 2 and sticky notes. The design of this study was Quasi Experimental with a nonequivalent control group design model, the research subject of The first semester biology of education students who were studying elementary mathematics. The results showed that the low ability of students mathematical structure sense was caused by several factors including the low response of elementary mathematics learning students 43.24%, low ability of student symbol sense of students are 51, 64%, construct 2 needs to be developed to respond to students who have basic math learning difficulties 63.21%, and 74.56% of students state that sticky notes are easier to apply, understandable and more practical. The ability of the structure is influenced by the learning model and the media used Keywords: Structure sense mathematics, instructional Media PermaLink | Plain Format | Corresponding Author (Hamdan Sugilar)

915	Mathematics	ABS-208
Drawing Graph of Quadratic Functions: What Affects It? T S Sumartini, I Maryati, M A Noordyana, T Sritresna, Basuki Institut Pendidikan Indonesia Garut Abstract The quadratic function of the part of mathematics that is dynamic. This gives the meaning that drawing graphs of quadratic functions can use a variety of different ways. The purpose of this study is to find out various ways of presenting graphs of quadratic functions. The sample of this study took two respondents who had learned quadratic function material. The study was conducted qualitatively by analyzing the way the graphs of quadratic functions are presented. The results showed that the effectiveness of drawing quadratic functions is influenced by the ability to think creatively Keywords: Quadratic Functions, Creative Thinking PermaLink | Plain Format | Corresponding Author (Tina Sri Sumartini)

916	Mathematics	ABS-473
A Study of Several Variable Selection Methods in Modelling The Mathematics Score of Indonesian Students in Programme for International Student Assessment (PISA) Based on Convex Penalized Likelihood Vera Maya Santi (a*), Khairil Anwar Notodiputro (b), Bagus Sartono (b) a) Department of Statistics, Faculty of Mathematics and Natural Science, Universitas Negeri Jakarta b) Department of Statistics, Faculty of Mathematics and Natural Science, Institut Pertanian Bogor Abstract Variable selection is an important topic in linear regression analysis. In practice, a large number of predictors usually are introduced at the initial stage of modeling to attenuate possible modeling biases. stepwise deletion and subset selection are usually used which can be computationally expensive and ignore stochastic errors in the variable selection process. In addition, the best subset selection of variables suffers from several disadvantages, the most severe of which is its a lack of stability. In this article, penalized likelihood approaches are proposed to handle these kinds of problems. The proposed methods select variables and estimate coefficients simultaneously. Some of penalty functions are used to produce sparse solutions. Based on the RMSE and GIC criteria, it was found that the factors affecting Indonesian mathematics scores from PISA with 148 independent variables showed that the SCAD penalty function had the best performance compared to LASSO, Ridge and MCP. LASSO produces 13 important variables for the model while SCAD has 11 variables which mean that the LASSO model is more complex than SCAD. The MCP produces a simpler model with 3 important variables but produces excessive bias.Ridge penalty has a worst performance based on all criteria. Keywords: Variable Selection; Penalized Likelihood; SCAD; LASSO; MCP; Ridge; GIC; RMSE. PermaLink | Plain Format | Corresponding Author (Vera Maya Santi)

917	Mathematics	ABS-245
Optimal Invesment Portfolio using Linear Algebra Basuki *1, Sukono*2, D. Sofyan*3., S.S. Madio, *4, N. Puspitasari*5 Institut Pendidikan Indonesia Garut *1, 3, 4, 5 Universitas Padjajaran Bandung *2 Abstract In this paper we discuss the issue of linear algebra on the investment portfolio optimization models. It was assumed that stock returns are analyzed have a certain distribution, so that the mean and variance and covariance between the separation can be determined. Return of some stock used to form a vector averaging, and the number of shares used as the basis to form a unit vector. While the variance of each stock as well as the covariance between stocks, is used to form a covariance matrix. The investment portfolio was formed consisting of several stocks, in order to maximize the expected return and minimize risk. The portfolio optimization was performed using linear algebra approach. The result is a formula used to determine the optimum composition of the portfolio weights. The resulting formula is very useful for the analysis of the investment portfolio optimization. Keywords: linear algebra, Optimal Invesment Portfolio PermaLink | Plain Format | Corresponding Author (Basuki Basuki)

918	Pharmacology	ABS-512
Metformin Use and High Density Lipoprotein-Cholesterol Level in Type 2 Diabetic Patients Sri Agung Aryastuti (a*), Asri Lestarini (a), Ni Putu Diah Witari (a) a)Faculty of Medicine and Health Science, Warmadewa University, Jl. Terompong No. 24 Denpasar, Bali-Indonesia sriagungary[at]gmail.com Abstract Metformin, a biguanide oral antidiabetic, is the initial treatment for patients with type 2 diabetes mellitus. Metformin is recommended either as a monotherapy or combination with the other antidiabetic agents. Some studies suggest that metformin treatments have been shown to be associated with improved the high density lipoprotein-cholesterol (HDL-C) level in type 2 diabetes mellitus by interfering with AMP-activated protein kinase (AMPK) pathway. Metformin activate AMPK that stimulates catabolic processes (glycolysis and fatty acid oxidation) and inhibits anabolic pathways (gluconeogenesis and fatty acid synthesis). This is a cross-sectional study aiming to compare HDL level in type 2 diabetic patients using metformin and non-metformin. A total of 138 patients were included in this study with mean age 59.93 (±9.49) years. In the metformin group, the median HDL-C level was 48 mg/dL, while in non-metformin group the median HDL-C level was 45 mg/dL. HDL-level in the metformin group was higher than non-metformin group but it is not statistically significant (p>0.05; Mann Whitney U test). Further studies are needed to investigate another oxidative stress parameter related to AMPK pathway. Keywords: metformin, HDL, type 2 diabetes mellitus PermaLink | Plain Format | Corresponding Author (Sri Agung Aryastuti)

919	Pharmacology	ABS-261
CYTOTOXIC ACTIVITY AND APOPTOSIS-INDUCING MECHANISM OF KISEUEUR (Antidesma tetrandrum blume) LEAVES AND BARK IN MCF-7 BREAST CANCER CELLS Siva Hamdani ; Chaidir ; Anas Subarnas; Doni Anshar Nuari Universitas Garut ; Badan Pengkajian dan Penerapan Teknologi; Universitas Padjadjaran; Universitas Garut Abstract Kiseueur (Antidesma tetrandrum blume) is an Indonesian native plant that is potential to developed to be an anticancer drug. This study aimed to determine the cytotoxic activities and apoptosis inducing mechanism of the extract and fraction of Kiseueur leaves and bark in breast cancer cell lines (MCF-7). Cytotoxic activity was carried out using the MTS assay. The expression of caspase 3 and caspase 9 pro-apoptotic proteins was observed by Western blot analysis.The results showed that the extract and fraction of Kiseueur leaves and bark had varied cytotoxic activities in breast cancer cell lines (MCF-7). Kiseueur bark extract had the strongest cytotoxic activity against MCF-7 cells with IC50 81.65 μg / mL. The extract of Kiseueur bark induced apoptotic mechanism through modulation of caspase 9 and caspase 3 protein expression. Keywords: Cytotoxic activity, Apoptosis, MCF-7, Antidesma tetrandrum PermaLink | Plain Format | Corresponding Author (Siva Hamdani)

920	Pharmacology	ABS-266
Molecular Docking Study of Antocyanidins to Epidermal Growth Factor Receptor as Anti Lung Cancer Riska Prasetiawati, Rahmawati, Benny Permana, Shendi Suryana, Novriyanti Lubis Universitas Garut Abstract Lung cancer is the leading cause of cancer deaths among another types. Epidermal Growth Factor Receptor (EGFR) is a potential target in cancer cells thats belong to Tyrosin Kinase receptors, which responsible for the growth of various parts of the cell. Anthocyanidin is an aglycone of anthocyanin which has antiproliferative activity based on its antioxidant properties. The aim of this study was to find natural metabolites compound from anthocyanidins as a candidate for anti lung cancer through interaction with EGFR and obtain predictive activity, absorption, distribution and toxicity of anthocyanidin compounds. All compounds were optimized with Autodock Tools then simulated in molecular docking and predicted its absorption, distribution and toxicity. Gefitinib, a well known of EGFR inhibitor was taken as the standard for comparative analysis. Malvidins physicochemical properties qualified on Lipinskis Rule of Five, and show its good bioavailability. Molecular docking simulation showed the lowest binding energy of Malvidin to the receptor. Prediction of absorption and distribution showed Malvidin had Caco-2, HIA and Protein Plasma Binding in sequence is 1.7590 nm.sec-1; 83.1034% and 94.9441%. It is also mutagenic but non carcinogenic. Based on these data, Malvidin has the potential to be an anti-lung cancer candidate through EGFR inhibition. Keywords: molecular docking, malvidin, toxicity, ADME, lung cancer PermaLink | Plain Format | Corresponding Author (Riska Prasetiawati)

921	Pharmacology	ABS-269
Study of Vaccines Vial Monitor Status and Potency at Eleven Province in Indonesia Mukhlissul Faatih (a*), Yuyun Yuniar (a), Reni Herman (b) a) Center for Research and Development of Health Resources and Services, NIHRD Indonesia Jl. Percetakan Negara 29 Jakarta Pusat Indonesia * faatih44[at]gmail.com b) Center for Research and Development of Biomedical and Basic Technology of Health, NIHRD Indonesia Abstract The Indonesian Ministry of Health responsible for the supply and distribution of logistics needed in the implementation of the Immunization Program at national, provincial, district, and health facility levels. This study discussed cold chain management of vaccines from Provincial Health Office to the health center facilities and tested the vaccine potency. We have used a cross-sectional study involving a multistage sampling. Primary health centers, clinics and hospitals were selected from each two districts of eleven provinces. The data were analyzed descriptively and analytically using Chi Square Test. Vaccine potency test was carried out by Kendrick test. This study confirmed that the cold chain management of vaccines at the provincial level was better than the districts and health center facilities. The quality of Vaccine Vial Monitor (VVM) was in gradually decline from provinces to districts and health center facilities. Potency test results of DPT and polio vaccines suggested that all vaccines are still qualified in all study sample locations. Keywords: vaccine vial monitor; potency test PermaLink | Plain Format | Corresponding Author (Mukhlissul Faatih)

922	Pharmacology	ABS-270
Antioxidant activity of water spinach and land spinach (Ipomoea aquatica) of Indonesia: A comparative study Ria Mariani, Farid Perdana, Faizah Min Fadhlillah, Atun Qowiyyah, Hemma Triyana Department of Pharmacy, Garut University, Jati 42B, Garut 44151, Indonesia Abstract Ipomoea aquatica is Convulvulaceae plant that is widely consumed in Southeast Asia as a vegetable. The plant contain various bioactive constituents, e.g. phenols and flavonoids. Water spinach and land spinach are two varieties of Ipomoea aquatica in Indoneaia. Both plants have been analyzed for their radical scavenging activity using DPPH (2,2-diphenyl-1-picrylhidrazil). Total phenol was measured using Folin Ciocalteau and total flavonoid was measured using AlCl3. Water spinach has higher antioxidant activity than land spinach and there were correlation between antioxidant activity and total phenol/flavonoid content. Keywords: Antioxidant, Ipomoea aquatica, phenol, flavonoid PermaLink | Plain Format | Corresponding Author (Ria Mariani)

923	Pharmacology	ABS-527
High Prevalence of Anemia Among Human Immunodeficiency Virus-Infected Patients Treated with Antiretroviral Therapy Sri Agung Aryastuti (a*), Sri Ratna Dewi (a), Putu Nita Cahyawati (a), Dewa Gede Budiyasa (b), Ketut Suryana (c), Sri Masyeni (a) a)Faculty of Medicine and Health Science, Warmadewa University, Jl. Terompong No. 24 Denpasar, Bali-Indonesia sriagungary[at]gmail.com b)Sanjiwani Hospital, Jl. Ciung Wanara No. 2 Gianyar, Bali-Indonesia c)Wangaya Hospital, Jl. Kartini No. 133 Denpasar, Bali-Indonesia Abstract Anemia is a common condition found among Human Immunodeficiency Virus (HIV)-infected patients. T-cells that are infected with HIV virus can directly suppress the growth of progenitor cells in the bone marrow so that affecting the hemopoiesis resulted in anemia. These hematological abnormalities could potentially cause serious clinical implications. This study was conducted to determine the prevalence of anemia in HIV-infected patients in Bali. A total of 243 medical record data from HIV-infected patients at Wangaya Hospital Denpasar Bali and Sanjiwani Hospital Gianyar Bali between 2009 -2017 were included in analysis. Prevalence of anemia in ART-naïve patients and in patients on ART were 60.8% and 40.3%, respectively. Leucopenia and thrombocytopenia were found 8.2% and 9.4%, respectively, in ART-naïve group. While in patients with ART group leucopenia and thrombocytopenia were accounted for 6.9% and 4.3%, respectively. There was a significant difference in prevalence of anemia between ART-naïve patients and patients on ART (60.8% vs 40.3%; p < 0.05). Although the prevalence of anemia was lower in patients on ART, but anemia continues to be common in a substantial portion of HIV-infected persons. Another studies are still needed to addressing the impact of anemia on HIV-infected individuals, as well as treatment strategies and future research directions. Keywords: anemia, HIV, antiretroviral therapy PermaLink | Plain Format | Corresponding Author (Sri Agung Aryastuti)

924	Pharmacology	ABS-278
DISSOLUTION PROFILE OF PARACETAMOL TABLETS WITH CHICKEN FEET GELATIN AS BINDER COMPARED WITH COMMERCIAL COW GELATIN Aji Najihudin (a*), Nurhabibah (a), Ayustina Permata (a), Nurul Auliasari (a), Framesti Frisma Sriarumtias (a) a) Fakultas MIPA, Universitas Garut (UNIGA), Garut, Indonesia *ajinajihudin[at]uniga.ac.id Abstract Gelatin is a biopolymer derived from collagen proteins extracted from the skin or animal bones.The aim of this research was to formulated paracetamol tablets by using chicken feet gelatin, evaluated tablets and dissolution test. The preparation of chicken feet gelatin was done by an acid method using 4% HCl solvent. Preparation of paracetamol tablets using chicken feet gelatin and commercial gelatin was done by wet granulation method with the variation of binder concentration of 1.5%, 3%, and 4.5%. The granules, tablets, and dissolution tests were evaluated. Testing of in vitro dissolution of paracetamol tablets was done by paddling method in phosphate buffer pH 5.8 as dissolution medium. The yield of chicken feet gelatin obtained was 5.06%. The results of evaluation paracetamol granules and tablets showed that six formulas are qualify except for the friability of F1 and F2. Paracetamol tablets using chicken feet gelatin as binder showed a faster dissolution profile and qualify compared to commercial gelatin binders. Paracetamol tablets using chicken feet gelatin as the binder with a concentration of 4.5% (formula 3) showed the best results of tablets evaluation and in the 30th minute dissolve as much as 81.55%, it showed the best dissolution profile. Keywords: Disolution, Paracetamol, chicken feet gelatin, wet granulation PermaLink | Plain Format | Corresponding Author (aji najihudin)

925	Pharmacology	ABS-310
ACUTE TOXICITY TEST OF Syzygium malaccense (L.) Merr & Perry on Swiss Webster FEMALE MICE Hesti Renggana, Deden Winda Suwandi, Atun Qowiyyah,Doni Anshar Nuari, Shopi Fauziah Departement of Pharmacy, Faculty of Mathematics and Natural Sciences Universitas Garut, Garut, Indonesia Abstract Obesity is a metabolic disease characterized by high levels of fat. Previous studies have reported that Jambu Bol leaves (Syzygium malaccense (L) Merr. & Perry) have the efficacy of Antiobesity. To ensure safety, acute toxicity testing is carried out. The test animals used were 24 female white mice, divided into 6 treatment groups. Group 1 as a control group was given aquades. Group 2-6 was given ethanol extract of guava leaves with doses of 300, 1000, 2000, 4000 and 5000 mg / KgBB. The test is carried out for 14 days where the preparation is only given once. The parameters of the study included behavioral tests on the first and 14th day, body weight every day, macropatology of vital organs and organ indexes on the 14th day. The results of all doses of extract did not show a decrease in body weight, behavior changes and macropatological changes but there were differences in organ indexes, so that Jambu Bol ethanol extract can be declared not toxic. Keywords: acute toxicity, Syzygium malaccense PermaLink | Plain Format | Corresponding Author (Hesti Renggana)

926	Pharmacology	ABS-617
Formulation and Evaluation Fast Dissolving Film Salbutamol Sulphate Using HPMC E15 Nurhabibah Nurhabibah*, Framesti Frisma Sriarumtias, Siti Fauziah, Nurul Auliasari, Siti Hindun Program Studi Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Garut, Jl. Raya Samarang No.52A, Garut, Indonesia *nurhabibah[at]uniga.ac.id Abstract Fast Dissolving Film (FDF) have ability to releasing active pharmaceutical rapidly in oral mucosal with increasing bioavaibility of active pharmaceutical due to first passing hepatic metabolism. The aim of the research was formulated and evaluated FDF salbutamol sulfat with HPMC E15 polymer use solvent casting method. FDF salbutamol sulfat with variation of concentration HPMC E15 polymer was resulted film who flexible and semi transparent. The results of the evaluation of thickness, weight variation, folding endurance, surface pH, moisture loss, moisture uptake and disintegration time of film for all formulation was comply with a requested, except weight variation of F4, disintegration time of F1, F2, F3 and F4. Keywords: Fast Disintegrating Film, Formulation, Evaluation, Salbutamol Sulphate, HPMC E15. PermaLink | Plain Format | Corresponding Author (Nurhabibah Nurhabibah)

927	Pharmacology	ABS-665
Anti-inflammatory Pharmacology Test in Rats Induced by Carrageenan Pande Ayu Naya Kasih Permatananda (a,b,*), Andi Alfia Muthmainnah Tanra (a,c), Maya Ganda Ratna (a), Chaerul Fadly Mochtar Luthfi Masiming (a), Aisyah Amirullah (a) (a). Faculty of Medicine, Nursing, and Public Health, Universitas Gadjah Mada, Yogyakarta, Indonesia *nayakasih[at]gmail.com (b). Faculty of Medicine and Health Science, Universitas Warmadewa, Denpasar, Indonesia (c). Faculty of Medicine, Universitas Tadaulako, Palu, Indonesia Abstract Inflammation is a local reaction from living tissue or cells to a stimulation or injury. This anti-inflammatory test aims to determine the effect of anti-inflammatory treatment on changes in edema volume in rat’s feet after induced by carrageenan. Anti-inflammatory that is used in this research is celecoxib. Celecoxib is a non-steroidal anti-inflammatory agent that works by inhibiting selective cyclooxigenase enzymes. In this pharmacological screening test, 2 wistar strains of white rats were tested, which were weighed before anti-inflammatory administration. The rats were divided into 2 groups, namely the negative and positive control group. As for the negative control, the treatment was given 0.9% NaCl as much as 4 mL per oral, while for positive control was given celecoxib 100 mg / 55.5 ml. the volume of edema in the rat’s feet was measured using pletismometer. We found that there was no significant difference in the volume of edema between the group given 0.9% NaCl and the group given celecoxib. Therefore, we conclude that celecoxib as an anti-inflammatory agent is not able to inhibit edema in rat’s feet. Keywords: anti-inflammatory, rats, celecoxib PermaLink | Plain Format | Corresponding Author (Pande Ayu Naya Kasih Permatananda)

928	Pharmacology	ABS-435
Phytochemical Test on Herbal Drinks "Loloh Cemcem" at Panglipuran Village, Bali Putu Nita Cahyawati (a*), Asri Lestarini (b), Tanjung Subrata (c), Ni Wayan Erly Sintya Dewi (d), I Gusti Putu Wiadnyana (e) a) Department of Pharmacology and Pharmacy, Faculty of Medicine and Health Sciences, Warmadewa University, Bali, Indonesia *putunitacahyawati[at]gmail.com b,c,d) Department of Physiology & Biochemistry, Faculty of Medicine and Health Sciences, Warmadewa University, Bali, Indonesia e) Department of IKK-IKP, Faculty of Medicine and Health Sciences, Warmadewa University, Bali, Indonesia Abstract "Loloh" is a traditional Balinese drink that is believed to be able to overcome certain diseases. The Balinese people make "loloh" independently for self-consumption or trading in small-scale home industry. The making of "loloh" is usually passed down from generation to generation. So, the outstanding circulation has not been standardized and with different ingredients. "Loloh cemcem" is one of the traditional drinks from The Penglipuran Village, Bangli Regency, Bali. This study aims to conduct phytochemical tests on "loloh cemcem" in Bali, especially from Penglipuran Village. Phytochemical tests include levels of alkaloids, steroids, terpenoids, phenolics, saponins, flavonoids, and tannins. The results of this study indicate that "loloh cemcem" produced in Penglipuran Village contains moderate levels of flavonoids and terpenoids (642.88 mg/100g), containing tannins, phenols, and alkaloids. In conclusion, "loloh cemcem" has the potential to be an antibacterial, antioxidant and another benefit that still needs further investigation. Keywords: loloh cemcem, Bali, flavonoids, terpenoids, antioxidant PermaLink | Plain Format | Corresponding Author (Putu Nita Cahyawati)

929	Pharmacology	ABS-439
Formulation and Evaluation Of Splash Body From Arabika Coffee Oil (Coffea arabica L.) Java Preanger Retty Handayani, Nurul Auliasari,Tiara Krisvia Oktaviany, Siti Hindun Faculty of Mathematics and Natural Sciences, University of Garut Jalan Jati No. 42B, Garut 44151, Indonesia rettyhandayani[at]gmail.com Abstract Java preanger arabica (Coffea arabica L.) coffee is a specialty coffee from Priangan, one of which is efficacious as a natural fragrance. The essential oil content in java preanger arabica (Coffea arabica L.) coffee beans includes Abhexon, Furaneol, Sotolon, Pentandion. The purpose of this study is to find out what percentage of the concentration of coffee extract gives a good aroma, how to formulate a safe and stable body splash preparation. The research methodology began with material collection, determination, making coffee roasting, soxletation with ether solvents, dosage formulations made with concentrations of one percent, three percent, six percent and evaluations including organoleptic testing, pH, viscosity, quality testing of body splash preparations (test spredibility, endurance test, spot test, adhesion test), irritation test, preference test, sharpness test and preference test. The evaluation results showed that the formula of body splash preparation with the concentration of three percent java preanger arabica (Coffea arabica L.) coffee oil was a safe, stable and preferred aroma because it was not too stinging and did not cause stains on clothes Keywords: Java preanger arabica coffee bean oil; body splash; natural fragrance PermaLink | Plain Format | Corresponding Author (Retty Handayani)

930	Pharmacology	ABS-445
Comparison of Kidney Damage in Ischemic Reperfusion Injury (IRI) and Renal Ablasion Putu Nita Cahyawati (a*) a) Department of Pharmacology and Pharmacy, Faculty of Medicine and Health Sciences, Warmadewa University, Bali, Indonesia *putunitacahyawati[at]gmail.com Abstract The kidneys are organs that play an important role in maintaining the balance of body fluid and removing metabolic waste products. The incidence and prevalence of kidneys disease continue to increase throughout the world. Various conditions can cause failure of kidney function. Acute kidney failure (ARF) can increase the risk of chronic kidney failure. The severity of the disease, duration, and frequency of ARF are predictive factors that are important for the patients condition. This study aims to compare the degree of kidney damage based on tubular injury scores in acute and chronic renal failure conditions using an experimental model of ischemic reperfusion injury and renal ablation. Eighteen male Swiss mice will be grouped into 3 treatment groups: the sham operation group (SO, n=6), the ischemic reperfusion injury group (IRI, n=6), and the renal ablation group (RA, n=6). Kidney tissue was stained with hematoxylin-eosin (HE) and tubular injury scores were assessed blindly. This study found that there were significant differences in tubular injury scores between the SO groups (0.43 \pm 0.49) and RA (3.6 \pm 0.70), but there were no significant differences between the SO groups (0.43 \pm 0.49) vs IRI (2.23 \pm 0.55) and IRI (2.23 \pm 0.55) vs RA (3.6 \pm 0.70). Based on the results it can be concluded that there are no differences in tubular injury scores between the ischemic reperfusion injury and renal ablation condition. Keywords: tubular injury, ischemic reperfusion injury, renal ablation PermaLink | Plain Format | Corresponding Author (Putu Nita Cahyawati)

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